The good news is no, it will not. However, a stringent regiment is best for short and long-term success, especially for men due to their levels of DHT compared to women. Think of it as the same as if you commit to going to the gym or plan a certain lifestyle diet change, continuity in schedule yields the best results. So, do not become overly worried if you miss a night or a full day or two here and there. That being said, if you are very irregular in your routine, some people can see a shed happen due to hormonal fluctuations, think of it as taking 2 steps forward and 1 step back. Making shampoos and or topicals a daily routine quickly becomes part of one’s daily lifestyle and becomes second nature.